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Preheat your oven to 375°F. Lightly grease a 9x13 inch baking dish or an 8x8 inch square baking dish.
Bring a large pot of salted water to a rolling boil. Add the elbow macaroni and cook according to package directions until al dente, about 7 to 9 minutes. Add the cauliflower florets to the boiling water during the last 3 to 4 minutes of the pasta cooking time. Drain the pasta and cauliflower well in a colander and set aside.
While the pasta is cooking, prepare the cheese sauce. In a medium saucepan, melt 1/4 cup of unsalted butter over medium heat. Whisk in the 1/4 cup of all-purpose flour and cook for 1 to 2 minutes, stirring constantly, until a smooth paste (roux) forms.
Gradually whisk in the 2 1/2 cups of milk, a little at a time, ensuring no lumps form. Continue to whisk constantly until the sauce thickens and comes to a gentle simmer, about 5 to 7 minutes.
Remove the saucepan from the heat. Stir in the 2 cups of shredded sharp cheddar cheese, 1/4 cup of grated Parmesan cheese, 1 teaspoon of salt, 1/2 teaspoon of freshly ground black pepper, and 1/8 teaspoon of ground nutmeg. Stir until the cheeses are completely melted and the sauce is smooth and creamy.
Add the cooked pasta and cauliflower florets to the cheese sauce. Stir gently until everything is evenly coated.
Pour the pasta and cauliflower mixture into the prepared baking dish. In a small bowl, combine the 1/2 cup of panko breadcrumbs, 2 tablespoons of grated Parmesan cheese, and 1 tablespoon of melted unsalted butter. Sprinkle this mixture evenly over the top of the pasta bake.
Bake in the preheated oven for 25 to 30 minutes, or until the top is golden brown and bubbly. Let the bake rest for 5 minutes before serving.

Preheat your oven to 375°F. Lightly grease a 9x13 inch baking dish or an 8x8 inch square baking dish.
Bring a large pot of salted water to a rolling boil. Add the elbow macaroni and cook according to package directions until al dente, about 7 to 9 minutes. Add the cauliflower florets to the boiling water during the last 3 to 4 minutes of the pasta cooking time. Drain the pasta and cauliflower well in a colander and set aside.
While the pasta is cooking, prepare the cheese sauce. In a medium saucepan, melt 1/4 cup of unsalted butter over medium heat. Whisk in the 1/4 cup of all-purpose flour and cook for 1 to 2 minutes, stirring constantly, until a smooth paste (roux) forms.
Gradually whisk in the 2 1/2 cups of milk, a little at a time, ensuring no lumps form. Continue to whisk constantly until the sauce thickens and comes to a gentle simmer, about 5 to 7 minutes.
Remove the saucepan from the heat. Stir in the 2 cups of shredded sharp cheddar cheese, 1/4 cup of grated Parmesan cheese, 1 teaspoon of salt, 1/2 teaspoon of freshly ground black pepper, and 1/8 teaspoon of ground nutmeg. Stir until the cheeses are completely melted and the sauce is smooth and creamy.
Add the cooked pasta and cauliflower florets to the cheese sauce. Stir gently until everything is evenly coated.
Pour the pasta and cauliflower mixture into the prepared baking dish. In a small bowl, combine the 1/2 cup of panko breadcrumbs, 2 tablespoons of grated Parmesan cheese, and 1 tablespoon of melted unsalted butter. Sprinkle this mixture evenly over the top of the pasta bake.
Bake in the preheated oven for 25 to 30 minutes, or until the top is golden brown and bubbly. Let the bake rest for 5 minutes before serving.